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For months, governmental officials around the world have appeared to want to forgo discussing the specter of long COVID. As a new review makes clear, that is wishful thinking\u2014and the latest COVID variants<\/a> may well kick long COVID into overdrive, a scenario that researchers and experts have been warning about for some time.<\/p>\n \u201cI think they (government agencies) are itching to pretend that COVID is over and that long COVID does not exist,\u201d says Ziyad Al-Aly, director of the Clinical Epidemiology Center at Veterans Affairs St. Louis Health Care System and lead author of the review. \u201cIt is much more pleasant to <\/strong>pretend as if <\/strong>emergency department visits<\/a> <\/strong>and hospitalizations<\/a> haven\u2019t been rising sharply this <\/strong>summer.\u201d<\/p>\n In a Nature Medicine<\/em> review<\/a> this week, Al-Aly and several other top researchers lay out a difficult truth: Long COVID has already affected an estimated 400 million people worldwide, a number the authors say is likely conservative, at an economic cost of about $1 trillion annually\u2014equivalent to 1% of the global economy.<\/p>\n Moreover, the risk of a person being hit with long COVID rises with repeated infections of the virus itself, and recent COVID activity has experts watching closely. As review co-author Eric Topol noted in a recent blog post<\/a>, the current COVID incursion is ramping up quickly, with one modeler estimating <\/strong>900,000<\/a> new infections per day in the U.S. alone.<\/p>\n \u201cThe new significant wave,\u201d Topol said<\/a> via X<\/a>. \u201cIt\u2019s hard to believe the we are well into our fifth year of this virus and not taking the requisite steps to gain control.\u201d<\/p>\n The new significant wave. It’s hard to believe the we’re well into our 5th year of this virus and not taking the requisite steps to gain control. \u2014 Eric Topol (@EricTopol) August 5, 2024<\/a><\/p><\/blockquote>\n <\/p>\n The virus is evolving incessantly. <\/strong>Multiple COVID subvariants, collectively nicknamed FLiRT, are powerfully present in the U.S., and reports from California<\/a> indicate that some patients are complaining of throat pain so strong it feels like they\u2019re \u201cswallowing razors or broken glass,\u201d according to the Los Angeles Times. Topol, meanwhile, says the Sato Lab<\/a> in Japan has characterized one of the newest COVID strains, KP.3.1.1, in a preprint <\/strong>as having \u201cthe most immune evasion and infectivity of any of the variants\u201d derived from previous powerful iterations of the JN.1 strain, which was prominent last winter.<\/p>\n Although the Centers for Disease Control and Prevention says that <\/strong>severe outcomes and deaths<\/a> from COVID have decreased substantially overall from the pandemic\u2019s early days, wastewater data<\/a> <\/strong>shows viral activity is \u201chigh\u2019 nationally and COVID-19 infections are growing or likely growing in 35 states<\/a>. More COVID infections mean more cases of long COVID. And long COVID is already exacting an enormous toll on both the people and economies<\/a> of the world.<\/p>\n Those are words you aren\u2019t hearing from many government bodies. <\/strong>But, the researchers say, the evidence tells the story.<\/p>\n \u201cDespite the dire impact of long COVID on individuals and society, I fear that many are still unaware of the danger,\u201d says Akiko Iwasaki, professor of immunology at Yale School of Medicine and co-lead investigator of the <\/strong>university\u2019s <\/strong>COVID-19 Recovery Study. \u201cThere is an urgent need to provide proper diagnosis and treatment for people living with long COVID.\u201d<\/p>\n The authors lay out a number of preventive policy recommendations, including increased use of masking, improved ventilation systems and a vaccination program that pairs COVID shots with season flu shots to extend their reach to improve uptake. <\/strong>But there\u2019s a genuine question as to whether enough folks are paying close attention for any of this to matter.<\/p>\n As the authors point out, a survey found that as of last August, one-third of American adults still hadn\u2019t even heard of long COVID. In reality, long COVID was identified and defined in the first full year of the pandemic, 2020, and it has been increasing its case count ever since.<\/strong><\/p>\n This form of COVID is particularly perilous because, for many people, its symptoms may last years (or a lifetime) and their effects may trigger all sorts of associated problems and costs. Long COVID \u201caffects nearly every organ system,\u201d the review notes, including the cardiovascular, immune, gastrointestinal and reproductive systems. While more than 200 symptoms<\/a> have been identified, common symptoms include memory problems, difficulty concentrating, fatigue, heart palpitations, chronic cough, shortness or breath and recurring headaches.<\/p>\n Chillingly, most people who develop long COVID did not have particularly vicious cases of the virus initially. That\u2019s in part because so many more people experience a<\/a> mild form<\/a> of COVID rather than a severe one. (Across most studies, long COVID risk does increase with the severity of the initial infection.) And each time people become reinfected with the virus, they\u2019re at risk of developing long COVID, even if they didn\u2019t experience it previously.<\/p>\n The authors note that studies on recovery from long COVID are \u201csparse and inconsistent.\u201d But those that have closely evaluated individual manifestations of the virus have found recovery rates to be fairly low at one year, and only 7% to 10% fully recovered after two years. For millions and millions of people, the debilitating effects of long COVID are just that.<\/p>\n The economic toll is its own story. A Census Bureau Household Pulse Survey in 2022 found that between 2 million and 4 million<\/a> working-age Americans were out of work because they were sidelined with the effects of long COVID. Meanwhile 20%<\/a> of<\/a> people with long COVID surveyed by the United Kingdom\u2019s Trades Union Congress said they were not working. Another 16% were working reduced schedules.<\/p>\n The $1 trillion estimated annual global economic hit involves Organization for Economic Cooperation and Development (OECD) countries due to \u201creductions in quality of life and labor force participation,\u201d the Nature Medicine<\/em> <\/em><\/strong>review says. And that price tag does not factor in the direct costs of healthcare, another likely category of deep financial fissure.<\/p>\n Al-Aly and his co-authors are pleading for governments, especially U.S. health agencies, to dramatically upgrade their levels of activity to investigate long COVID, learn more about its mechanisms and pathways, and develop vaccines that better block infection. They\u2019re also pushing for large-scale platform trials to test multiple drugs simultaneously, so we can quickly learn what works and what doesn\u2019t.<\/p>\n\n\n
Including updates on the new boosters and #LongCovid<\/a>.
In Ground Truths (link found in my profile) pic.twitter.com\/Et1M7MKhbV<\/a><\/p>\n